Development of virus-like particles with inbuilt immunostimulatory properties as vaccine candidates

S Collett; L Earnest; J Carrera Montoya; MA Edeling; A Yap; CY Wong; D Christiansen; J Roberts; J Mumford; V Lecouturier; V Pavot; S Marco; JK Loi; C Simmons; SA Gulab; JM Mackenzie; A Elbourne; PA Ramsland; G Cameron; D Hans; DI Godfrey; J Torresi

Journal article

Development of virus-like particles with inbuilt immunostimulatory properties as vaccine candidates

S Collett, L Earnest, J Carrera Montoya, MA Edeling, A Yap, CY Wong, D Christiansen, J Roberts, J Mumford, V Lecouturier, V Pavot, S Marco, JK Loi, C Simmons, SA Gulab, JM Mackenzie, A Elbourne, PA Ramsland, G Cameron, D Hans Show all

Frontiers in Microbiology | FRONTIERS MEDIA SA | Published : 2023

DOI: 10.3389/fmicb.2023.1065609

Abstract

The development of virus-like particle (VLP) based vaccines for human papillomavirus, hepatitis B and hepatitis E viruses represented a breakthrough in vaccine development. However, for dengue and COVID-19, technical complications, such as an incomplete understanding of the requirements for protective immunity, but also limitations in processes to manufacture VLP vaccines for enveloped viruses to large scale, have hampered VLP vaccine development. Selecting the right adjuvant is also an important consideration to ensure that a VLP vaccine induces protective antibody and T cell responses. For diseases like COVID-19 and dengue fever caused by RNA viruses that exist as families of viral variant..

View full abstract

University of Melbourne Researchers

Simon Collett Author

Linda Earnest Author

Melissa Barrow Author

Ashley Yap Author

Related Projects (4)

ANTIGEN PRESENTATION, RECOGNITION AND THE IMMUNE RESPONSE

This program focuses on understanding the development of immunity during infection or inflammatory diseases using a broad array of technique..

UNCONVENTIONAL T CELLS IN HEALTH AND DISEASE

The human immune system comprises many different types of cells that can detect foreign molecules. My research will lead the way to understa..

Unconventional T cells: Fundamental biology and therapeutic potential

HIGH RESOLUTION ATOMIC FORCE MICROSCOPY FACILITY FOR BIONANOTECHNOLOGY

This project aims to establish a collaborative high resolution atomic force microscopy facility. Nanoscale surface structure and the complex..

Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This work was supported by a grant from NHMRC MRFF 2020 COVID-19 Vaccine Candidate Research, Australia (APP2013957) and an unrestricted research grant from Sanofi Pasteur. The research was performed in part at the RMIT Micro Nano Research Facility (MNRF) in the Victorian Node of the Australian National Fabrication Facility (ANFF). The Cypher ES AFM instrument was funded in part by grant LE170100096 from the Australian Research Council (ARC). SC was supported by a research training program stipend scholarship from the Australian Government, Department of Education and Training. AE acknowledges support from the Jack Brockhoff Foundation (JBF Grant number 4655-2019) and was supported by an Australian Research Council (ARC) Discovery Early Career Research Award (DECRA) (DE220100511). JT acknowledges support from the National Health and Medical Research Council of Australia (APP1181580). DG was supported by an NHMRC Senior Principal Research Fellowship (1117766) and an NHMRC Investigator Award (2008913), and acknowledges support from the National Health and Medical Research Council of Australia (NHMRC; 1113293). JT and DG acknowledge support from the Jack Ma Foundation for parts of the SARS-CoV-2 VLP work in this manuscript.